C. elegans Host/Pathogen Research
Zhang G, Sachse M, Prevost M-C, Luallen RJ, Troemel ER, Félix M-A (2016) A large collection of novel nematode-infecting microsporidia and their diverse interactions with Caenorhabditis elegans and other related nematodes. PLoS Pathog 12(12):e1006093. doi:10.1371/journal.ppat.1006093
Luallen RJ, Reinke AW, Tong L, Botts M, Félix M-A, Troemel ER (2016) Discovery of a natural microsporidian pathogen with a broad tissue tropism in Caenorhabditis elegans. PLoS Pathog 12(6):e1005724. doi:10.1371/journal.ppat.1005724
Balla KM, Luallen RJ, Bakowski MA, and Troemel ER (2016) Cell-to-cell spread of microsporidia causes Caenorhabditis elegans organs to form syncytia. Nature Microbiol. 1:16144. doi:10.1038/nmicrobiol.2016.144
Luallen RJ, Bakowski MA, Troemel ER (2015) Characterization of microsporidia-induced developmental arrest and a transmembrane leucine-rich repeat protein in Caenorhabditis elegans. PLoS One 10(4):e0124065. doi:10.1371/journal.pone.0124065
Luallen RJ, Troemel ER (2014). Breaking barriers: a GPCR triggers immunity in nematodes. Nature Immunol. 15:826-8 doi:10.1038/ni.2963 (Review).
Bakowski MA, Luallen RJ, Troemel ER. Microsporidia infection in Caenorhabditis elegans and other nematodes. In: L. Weiss & J. Becnel (Eds.) Microsporidia: Pathogens of Opportunity (Wiley, IA), 2014. p 341-56.
HIV Research
Zhang H, Fu H, Luallen RJ, Liu B, Lee FH, Doms RW, Geng Y (2015) Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans. Vaccine 33(39):5140-7. doi:10.1016/j.vaccine.2015.08.012
U.S. Patent 8,202,523, issued June 12, 2012; International patent application no. PCT/US2006/037302. "Glycosylated polypeptides produced in yeast mutants and methods of use thereof." Geng, Y. and Luallen, R.J.
Agrawal-Gamse C, Luallen RJ, Liu B, Fu H, Lee FH, Geng Y, Doms RW (2011) Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans. J Virol. 85(1):470-80. doi:10.1128/JVI.01349-10
Luallen RJ, Agrawal-Gamse C, Fu H, Smith D, Doms RW, Geng Y (2010) Antibodies against Manα1,2-Manα1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV. Glycobiology 20(3):280-6. doi:10.1093/glycob/cwp184
Luallen RJ, Fu H, Agrawal-Gamse C, Mboudjeka I, Huang W, Lee F-H, Wang L-X, Doms RW, Geng Y (2009) A yeast glycoprotein shows high affinity binding to the broadly neutralizing HIV antibody 2G12 and effectively inhibits gp120 interactions with 2G12 and DC-SIGN. J Virol. 83(10):4861-70. doi:10.1128/JVI.02537-08
Luallen RJ, Lin J, Fu H, Cai KK, Agrawal C, Mboudjeka I, Lee F-H, Montefiori D, Smith DF, Doms RW, Geng Y (2008) An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing HIV-1 antibody 2G12 and elicits mannose-specific, gp120-binding antibodies. J Virol. 82(13):6447-57. doi:10.1128/JVI.00412-08