Publications

Host-Microbe Interaction Research

Rivera DE, Poirier K, Moore S, Nicolle O, Morgan E, Longares JF, Singh A, Michaux G, Felix MA*, Luallen R* (2024) Dynamics of gut colonization by commensal and pathogenic bacteria that adhere to the intestinal epithelium. bioRxiv. doi: 10.1101/2024.10.24.620080 *co-corresponding authors

Poirier K, Luallen RJ*, Rivera D* (2024) RNA fluorescence in situ hybridization (FISH) as a method to visualize bacterial colonization in the C. elegans gut. microPublication Biology. doi: 10.17912/micropub.biology.001044. *co-corresponding authors

Singh A and Luallen RJ* (2024) Understanding the factors regulating host–microbiome interactions using Caenorhabditis elegans. Phil. Trans. R. Soc. B379: 20230059. doi: 10.1098/rstb.2023.0059 *corresponding author

Tran TD and Luallen RJ* (2023) An organismal understanding of C. elegans innate immune responses from pathogen recognition to multigenerational resistance. Sem. Cell. Dev. Biol. 154, 77-84 doi: https://doi.org/10.1016/j.semcdb.2023.03.005 *corresponding author

Wadi L, El Jarkass HT#, Tran TD#, Islah N, Luallen RJ, Reinke AW* (2023) Genomic and phenotypic evolution of nematode-infecting microsporidia. PLoS Pathog 19(7): e1011510. https://doi.org/10.1371/journal.ppat.1011510 #equal contribution, *corresponding author

Mok C*, Xiao MA, Wan YC, Zhao W, Ahmed SM, Luallen RJ, Reinke AW* (2023) High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits. PLoS Pathog. 19(3): e1011225. doi: 10.1371/journal.ppat.1011225. *corresponding author

Rivera DE, Lažetić V, Troemel ER, Luallen RJ* (2022) RNA Fluorescence in situ Hybridization (FISH) to Visualize Microbial Colonization and Infection in Caenorhabditis elegans Intestines. J. Vis. Exp. (185), e63980, doi:10.3791/63980.*corresponding author (pdf here) *corresponding author

Part of the collection –  Methods for Microbiome Research in Caenorhabditis elegans

Tran TD, Ali MA, Lee D, Félix M-A, Luallen RJ* (2022) Bacterial filamentation as a mechanism for cell-to-cell spread within an animal host. Nature Commun. 13(1):693, doi: 10.1038/s41467-022-28297-6 *corresponding author

News items: Thread spread - A never-before-seen way bacteria infect cells | Scientists Discover A Novel Way That Bacteria Infect Cells

Behind the Paper article at Nature Portfolio: Threading for spreading

Selected for Editor’s Highlights in Nature Communications: Editor’s Highlights

Morgan E, Longares JF, Felix MA, Luallen RJ* (2021) Selective cleaning of wild Caenorhabditis nematodes to enrich for intestinal microbiome bacteria. J. Vis. Exp. (174), e62937, doi: 10.3791/62937. *corresponding author (pdf here)

Panek J, Gang S, Reddy KC, Luallen RJ, Fulzele A, Bennet EJ, Troemel ER* (2020) A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in C. elegans. PNAS 117(14): 7950-60. doi:10.1073/pnas.1918417117 *corresponding author

Zhang G, Sachse M, Prevost M-C, Luallen RJ, Troemel ER, Felix M-A* (2016) A large collection of novel nematode-infecting microsporidia and their diverse interactions with Caenorhabditis elegans and other related nematodes. PLoS Pathog 12(12):e1006093. doi:10.1371/journal.ppat.1006093 *corresponding author

Luallen RJ, Reinke AW, Tong L, Botts M, Felix M-A, Troemel ER* (2016) Discovery of a natural microsporidian pathogen with a broad tissue tropism in Caenorhabditis elegans. PLoS Pathog 12(6):e1005724. doi:10.1371/journal.ppat.1005724 *corresponding author

Balla KM, Luallen RJ, Bakowski MA, and Troemel ER* (2016) Cell-to-cell spread of microsporidia causes Caenorhabditis elegans organs to form syncytia. Nature Microbiol. 1:16144. doi:10.1038/nmicrobiol.2016.144 *corresponding author

Luallen RJ, Bakowski MA, Troemel ER* (2015) Characterization of microsporidia-induced developmental arrest and a transmembrane leucine-rich repeat protein in Caenorhabditis elegans. PLoS One 10(4):e0124065. doi:10.1371/journal.pone.0124065 *corresponding author

Luallen RJ, Troemel ER (2014). Breaking barriers: a GPCR triggers immunity in nematodes. Nature Immunol. 15:826-8 doi:10.1038/ni.2963 (Perspective).

Bakowski MA, Luallen RJ, Troemel ER. Microsporidia infection in Caenorhabditis elegans and other nematodes. In: L. Weiss & J. Becnel (Eds.) Microsporidia: Pathogens of Opportunity (Wiley, IA), 2014. p 341-56.

Prior HIV Research

Zhang H, Fu H, Luallen RJ, Liu B, Lee FH, Doms RW, Geng Y* (2015) Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans. Vaccine 33(39):5140-7. doi:10.1016/j.vaccine.2015.08.012 *corresponding author

U.S. Patent 8,202,523, issued June 12, 2012; International patent application no. PCT/US2006/037302. "Glycosylated polypeptides produced in yeast mutants and methods of use thereof." Geng, Y. and Luallen, R.J.

Agrawal-Gamse C, Luallen RJ, Liu B, Fu H, Lee FH, Geng Y, Doms RW* (2011) Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans. J Virol. 85(1):470-80. doi:10.1128/JVI.01349-10 *corresponding author

Luallen RJ, Agrawal-Gamse C, Fu H, Smith D, Doms RW, Geng Y* (2010) Antibodies against Manα1,2-Manα1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV. Glycobiology 20(3):280-6. doi:10.1093/glycob/cwp184 *corresponding author

Luallen RJ, Fu H, Agrawal-Gamse C, Mboudjeka I, Huang W, Lee F-H, Wang L-X, Doms RW, Geng Y* (2009) A yeast glycoprotein shows high affinity binding to the broadly neutralizing HIV antibody 2G12 and effectively inhibits gp120 interactions with 2G12 and DC-SIGN. J Virol. 83(10):4861-70. doi:10.1128/JVI.02537-08 *corresponding author

Luallen RJ, Lin J, Fu H, Cai KK, Agrawal C, Mboudjeka I, Lee F-H, Montefiori D, Smith DF, Doms RW, Geng Y* (2008) An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing HIV-1 antibody 2G12 and elicits mannose-specific, gp120-binding antibodies. J Virol. 82(13):6447-57. doi:10.1128/JVI.00412-08 *corresponding author